Methodology to estimate natural- and vaccine-induced antibodies to SARS-CoV-2 in a large geographic regionArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] 95% CI antibody approach blood draw collected conducted COVID-19 case data-driven defined estimate Factors immune response methodology natural infection Older pandemic parameter participant Reproduction number SARS-CoV-2 serological data serological survey statistical vaccination vaccine-induced antibody [DOI] 10.1371/journal.pone.0273694 PMC 바로가기
SARS-CoV-2 Seroconversion in Response to Infection and Vaccination: a Time Series Local Study in BrazilArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age Analysis anti-Spike IgG antibody Antigen Brazil coronavirus coronavirus disease COVID-19 COVID-19 vaccination determine effective Effectiveness Fatality rate fraction Gender help humoral IgG Infection infection rate information nucleocapsid nucleocapsid antigen pandemic progression raised reactive response response to vaccination SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconversion rate seroconvertion serological serological data serological survey Seroprevalence Sery spike Support the disease the SARS-CoV-2 time vaccination vaccination. vaccine dose [DOI] 10.1128/spectrum.01026-22 PMC 바로가기
Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker DiscoveryCOVID-19 바이오마커 발견을 위한 기계 학습을 통한 혈청 단백질체학 및 임상 데이터의 심층 표현형 결합Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 유전자 메커니즘, [키워드] analyzed Biomarker Biomarkers cardiometabolic CD200R1 Central nervous system clinical Clinical practice contributed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient dataset deep disease disease severity Diseases downregulated enrolled Factors IL6 IMPROVE Inflammation KIT LTBP2 lymphocyte lymphocyte counts machine learning MATN3 MCP1 MOST MRAP natural history neurologic neurologic disease neutrophil nine outcome pathology persistence Phenotyping Protective Protein proximity extension assay proximity extension assay. sera serological data serum biomarker serum biomarkers severe cases small sample size statistical TRANCE unique variable [DOI] 10.3390/ijms23169161 PMC 바로가기 [Article Type] Article
Six months SARS-CoV-2 serology in a cohort of mRNA vaccinated subjects over 90 years old90세 이상의 mRNA 백신 접종 대상자 집단에서 6개월 SARS-CoV-2 혈청 검사Article Published on 2022-07-202022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration Adults age Ageing Antibody Response Antibody titre Cohort COVID-19 vaccine doses Effectiveness Efficacy evaluated facilitate Factor immune system Intention knowledge mRNA Patient profile receive SARS-CoV-2 serological data serology serostatus Sex subject vaccination Vaccine [DOI] 10.1038/s41598-022-15148-z PMC 바로가기 [Article Type] Article
Evaluation of a Multiplex Bead Assay against Single-Target Assays for Detection of IgG Antibodies to SARS-CoV-2SARS-CoV-2에 대한 IgG 항체 검출을 위한 단일 표적 분석에 대한 다중 비드 분석 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Against antibody Antibody detection antibody reactivity Antigen antigens assays bead coefficient Collection convalescent COVID-19 COVID-19 symptom detect detection determinant determinants diagnostic diagnostic sensitivity diagnostic specificity diagnostic test diagnostic tests domain estimate evaluated exhibited highest highlight Human IgG immunoassay implementation include individual Infection inherent MOST multiple antigen multiplex Multiplex assay multiplex bead assay. nucleic acid nucleocapsid protein offer performed Population RBD reduced Reporting Research responses reverse transcriptase reverse transcriptase PCR RT-PCR S1 RBD SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 seroprevalence SARS-CoV-2 spike protein sensitivity Sensitivity and specificity serological assays serological data serological test Seropositivity serum specific antigen specificity specimen specimens Spike protein subject symptom onset target targets test results tested [DOI] 10.1128/spectrum.01054-22 PMC 바로가기 [Article Type] Article
Development and Implementation of Dried Blood Spot-Based COVID-19 Serological Assays for Epidemiologic Studies역학 연구를 위한 건조혈점 기반 COVID-19 혈청학적 분석의 개발 및 구현Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition alternative ambient ambient temperatures antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses Bay Blood changes in Cohort Community comparable COVID-19 COVID-19 pandemic Critical DBS sample DBS samples detect development dried blood spot Dried blood spots East Effectiveness enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays estimate estimation Immunity implementation inaccessible Infection Infectious disease Infectious diseases invasive Measures pandemic participant pathogen pathogen-specific phlebotomy Postinfection Prevalence Prevent public health measures Public health responses refrigeration risk factor Risk factors San Francisco SARS-CoV-2 SARS-COV-2 infection serological serological assays serological data serological studies serological surveillance serological survey serology Seroprevalence seroprevalence. specific antibodies Spread stability storage study participant Study participants study population Surveillance Traditional vaccination venipuncture venous venous blood [DOI] 10.1128/spectrum.02471-21 PMC 바로가기 [Article Type] Article
High titer of antibody against the SARS-CoV-2 spike protein among patients receiving neutralizing antibody cocktail therapy with REGN-COVREGN-COV로 중화 항체 칵테일 요법을 받는 환자 중 SARS-CoV-2 스파이크 단백질에 대한 높은 항체가Article Published on 2022-06-012022-09-11 Journal: Infection [Category] COVID19(2023년), SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antibody Antibody titer Antibody titers Architect body weight Casirivimab casirivimab/imdevimab clinical benefit cocktail collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 effective elevated evaluated IgG Imdevimab Immunoglobulin Linear regression model median Neutralizing antibodies neutralizing antibody nine nucleocapsid protein Patient patients with COVID-19 Prophylactic Prophylaxis receiving Receptor-binding domain REGN-COV remained respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2. serological serological data severe acute respiratory syndrome Coronavirus shown simple linear regression Spike protein Support the receptor-binding domain the SARS-CoV-2 therapeutic therapy treated Treatment were assessed [DOI] 10.1007/s15010-022-01779-x PMC 바로가기 [Article Type] Article
Long-Term Antibody Response and Vaccination Efficacy in Patients with COVID-19: A Single Center One-Year Prospective Study from the Czech RepublicCOVID-19 환자의 장기 항체 반응 및 예방 접종 효능: 체코의 단일 센터 1년 전향적 연구Article Published on 2022-03-042022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Admission analyzed antibody Antibody Response Antibody responses antigen detection center characterized Cohort courses COVID-19 patient COVID-19 patients Czech Republic diagnosis of SARS-CoV-2 diagnostic disease Dynamics ELISA enrolled Evidence high correlation hospitalized patient hospitalized patients IgA IgG IgG antibodies IgG antibody IgG level IgG levels IgM and IgG indicated Infection Laboratory neutralization test Patient PCR performed positive positive antibody response positive antibody responses Prospective Prospective Study Reinfection response Sample SARS-CoV-2 SARS-COV-2 infection sensitivity serological data serology significantly specific antibodies specific antibody sustained the SARS-CoV-2 vaccination Virus neutralization virus neutralization test Virus neutralization test. VNT [DOI] 10.3390/v14030526 PMC 바로가기 [Article Type] Article
Estimating SARS-CoV-2 Seroprevalence in Canadian Blood Donors, April 2020 to March 2021: Improving Accuracy with Multiple Assays2020년 4월부터 2021년 3월까지 캐나다 헌혈자의 SARS-CoV-2 혈청유병률 추정: 다중 분석으로 정확도 개선Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI Abbott advent Analysis Antibody Response antibody tests approach approach Architect assays blood donor Blood donors can be used Chicago IL cross-sectional cross-sectional design cross-sectional study diagnostic diagnostic testing disease Epidemics evaluate evaluated fatality full-length spike glycoprotein gold gold standard house identify IgG IgG antibodies IgG ELISA Improving indicate Infection infections laboratory assay laboratory assays latent class latent class analysis less Multiple nucleocapsid nucleocapsid antigen occur Pandemics Prevalence provide public health random RBD Receptor binding domain recognizing reference standard Reference standards repeated resulting SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody Sensitivity and specificity sera serological data serological studies SEROLOGICAL STUDY Seropositivity Seroprevalence seroreversion silent spike spike glycoprotein Support Surveillance vaccination [DOI] 10.1128/spectrum.02563-21 PMC 바로가기 [Article Type] Research Article
Is Better Standardization of Therapeutic Antibody Quality in Emerging Diseases Epidemics Possible?Immunology Published on 2022-02-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] activating anti-SARS-CoV-2 antibody antibody approach assessments average Better calibrated Cell characterisation collected comparable complement component convalescent convalescent plasma COVID-19 COVID-19 epidemic COVID-19 patient decrease effort evidenced expressed Immunocompromised lack NAbs neutralisation neutralising antibody passive antibody therapy positive correlation Quality ranged SARS-CoV-2 SARS-CoV-2 specific antibodies SARS-CoV-2–specific antibody sera serological data severity Standard Standardization the disease titre virus WHO wild-type SARS-CoV-2 wild-type virus neutralization assay [DOI] 10.3389/fimmu.2022.816159 PMC 바로가기 [Article Type] Immunology